Dr. Wold is the Bren Professor of Molecular Biology and Director of the Beckman Institute at Caltech. She began studying gene regulation during her Ph.D. work at Caltech, and developed methods for studying cis-regulatory function during postdoctoral work at Columbia. She joined the biology faculty at Caltech in 1981 where she and her colleagues study the architecture and logic of gene networks that drive cell state transitions. A recurring theme has been discovering how transcription machinery is deployed in the living cell nucleus. Recent work emphasizes new ways to quantitatively map the inputs and outputs of gene networks in a genome-wide manner using “next generation” ultra-high throughput DNA sequencing, and applying these methods to muscle and brain networks.